LDG - Video-FAQs

{"hasPart": [{"@type": "ItemList","name": "Sehen Sie sich unsere kurzen Videoantworten auf die am häufigsten gestellten Fragen zur dendritischen Zelltherapie und zu LDG an.","itemListElement": [{"@type": "VideoObject","name": "Haben Sie Ihr eigenes Labor?","uploadDate": "2025-09-01","description": "Unser eigenes hochmodernes Labor","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover16x9_newLab-1.jpg","contentUrl": "https://vimeo.com/1107119274","transcript": "Well, as you know, our dendritic cells are classified worldwide as ATMPs, which mean, which means advanced technology medicine or products. So a lot of quality control things concerning GCP, concerning GMP, which means good manufacturing practice must be fulfilled. Technique is developing all the time. And so the decision was made last year that we built a completely new laboratory which fulfills all the criteria at the moment and the criteria coming up the next 10 years. So we, uh, invested a lot to build a very, very brand new laboratory with a very high production, uh, capacity to produce at the highest level possible, our dendritic cells. This laboratory, of course, was then certified by the authorities in Germany, certified first by the provincial authorities and then federal authorities. The Paul Ehrlich Institute together with the Regierungsprasidium. This is the name of the provincial authorities. Well, and I think we, we did a very good job in a very short time. Normally, you need something like one and a half years to produce something like that. Uh, we need... We did it in seven months. And actually since begin of April, we are now producing in this new lab- new laboratory, uh, with a very high production capacity at a very, very high level and a very high security level that our process very well defined and fulfill all the criteria that these products, according to the ATMP laws, must fulfill."},{"@type": "VideoObject","name": "Reduziert Strahlentherapie die Wirksamkeit von DCT?","uploadDate": "2025-09-01","description": "DCT mit Strahlentherapie.","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover16x9_dctWithRadiotherapy.jpg","contentUrl": "https://vimeo.com/1107118692","transcript": "There have been several studies showing that dendritic cell therapy in combination with radiotherapy has very, very good results. Our group ourselves, we did not make these studies, but other groups, like Asian groups and Netherland groups, showed this. Of course, you cannot do it completely in parallel because when you do a radiotherapy, you, you are there every day, so you cannot come in between some days to Germany to get a dendritic cell therapy. We normally recommend to do first a dendritic ce- cell therapy and afterwards the radiotherapy."},{"@type": "VideoObject","name": "Was ist DCT?","uploadDate": "2025-09-01","description": "Was ist DCT?","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_whatIsDct.jpg","contentUrl": "https://vimeo.com/1047366296","transcript": "What is dendritic cell therapy, and why dendritic cell therapy? So you must imagine in every one of us, every day some cancers arise. Nevertheless, our immune system is capable to detect this cancer cell and destroy that. Meaning our immune system is very, very good, because if you calculate this on 80 years, we have, uh, our immune system has an effectivity of 99.999%. This is super in eliminating tumors. So some, very seldom it happens that these tumors are not detected for whatsoever reason, and the tumor can rise. In bad case, it can also metastasize. So the idea of a dendritic cell therapy is to give some extra learning for the den- for the immune system of the body, meaning taking out, outside the body, the antigens, which we need, meaning tumor fragments or tumor cells, and bring them together in a perfect atmosphere with the cells that are responsible for detecting these tumor cells, the dendritic cells. And train them that this little gap in the otherwise perfect working, uh, immunologic system is closed."},{"@type": "VideoObject","name": "Was ist von DCT hinsichtlich der Ergebnisse zu erwarten?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_whatToExpect.jpg","contentUrl": "https://vimeo.com/1047367964","transcript": "So what can we expect from a dendritic cell therapy? Dendritic cell therapy is highly effective. We have response rates between 60 and 65% according to oncologic criteria. We have-- we can avoid relapses in the adjuvant situation. Anyhow, uh, this is not... a promise for healing, although we have complete remissions and we have a lot of partial responses of the patient and a lot of patients tumor-free after dendritic cell therapy in the adjuvant situation. So we can classify the dendritic cell therapy as a very new, very highly effective therapy with very few side effects."},{"@type": "VideoObject","name": "Mit wem findet mein Beratungsgespräch statt und gibt es eine Nachbetreuung?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_whoIsMyConsulationWith.jpg","contentUrl": "https://vimeo.com/1047418372","transcript": "With regards to who will be the doctor treating you and how is my follow-up as a patient afterwards. Well, Zoom calls or personal consultations are, in 99% of the cases, made by me. And the follow-up is quite easy. Patients do not have to come to Germany to make their follow-up because every patient is in a follow-up program anyhow from his treating doctors in his home country. And it's turned out to be very effective that the patient send me their medical reports when they had examinations, uh, by email or even if it's, uh, bigger data volume, like CTs or MRIs, you also can transfer, uh, WeTransfer to me, and then I can have an online consultation with the patient again, either by Zoom or either by, uh, email."},{"@type": "VideoObject","name": "Was ist Laboratories Dr. Gansauge (LDG)?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover-fullControlOfLifecycle.jpg","contentUrl": "https://vimeo.com/1047355317","transcript": "So the question is, what is the LDG? The Laboratories Dr. Ganzerl, yeah. This means we are here in this clinic working with the patients, meaning here we take the blood and here we give the cells back. But in these seven days, which are in between, the blood is processed in our own laboratory. This laboratory underlies strict guidelines and laws from the drug law in Germany, but also the European medical agencies, the controls of, uh, different governmental structures who control that we do everything right and okay. Uh, meaning the blood, when it's taken here, it goes into our laboratory. Then all the quality assurance and quality control tests are made, meaning we look for, uh, hepatitis, for HIV, for infection criteria. We then bring the blood into the clean room, which is a, a class A clean room, meaning we produce at zero particles per cube meter. And then you must imagine, let's say we have 200 mL of blood. So first we must separate the serum. This is 100 milliliter, let's say. So from this 200 milliliter, we're now at 100 milliliter. Then we have to get rid of the red blood cells, because these ones we also do not need for the production. Then remains one mL out of these 200, which are the white blood cells. From the white blood cells, we also don't need so many, because most are neutrophil granulocytes, which we isolate then over ƒ, if you call ƒ density gradients. And then we have the mononuclear cells, meaning these are the, the monocytes plus the lymphocytes. These lymphocytes are then also isolated because we don't need them, because we just want the monocytes. Meaning out of 200 mL in the end, something remains like 0.1 mL. Uh, this one comes down into culture, and, uh, the production process of the dendritic cell, uh, the, the dendritic cells starts. This production pre- uh, process goes by adding different cytokines and growth factors. Uh, and after seven days, the cells are ready to be harvested, and then they are filled into syringes and brought back to the clinic and injected into the patients. What is very important for us, that the complete production process stays under control of few people, meaning I'm not only the doctor taking the blood, I'm also the production manager of our own laboratory where we produce these cells according to the German and European laws."},{"@type": "VideoObject","name": "Wie lange dauert es, bis ich die DCT erhalte?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_howlongdoesittake.jpg","contentUrl": "https://vimeo.com/1047359056","transcript": "With regards to waiting times or how long does it take from the first contact until the patient gets his dendritic cell therapy, we have this first time, which is most over email, where we discuss with the patient, we have Zoom calls, we see whether the patient qualifies for dendritic cell therapy. This takes not more than one week, and then, uh, we normally can make appointments within two to four weeks for the patients, and then comes the one-week therapy."},{"@type": "VideoObject","name": "Wie beginnt der Prozess und wie läuft er für die Patientinnen und Patienten ab?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover-theProcessForTheClient.jpg","contentUrl": "https://vimeo.com/1047363027","transcript": "How does the process start, and how is the process for the patient? Normally, patient get into touch with us via email or via telephone. S-- then, we first want to see the last medical reports, m- getting to know something about the patients, to see whether this patient qualifies for dendritic cell therapy. This is the first step. The second step is we try to find an appointment, because the patients must come in total three times to our outpatient clinic here in Berg, beautiful region close to Munich. Um... At the first appointment, we, uh, we make the informed consent. We explain everything again to the patient. We, uh, give also our ideas concerning the other cancer tr- therapies which are possible. Then the patient has some time to think about, and the next day, in the morning, patient comes, and we draw the blood from the patient. This complete process lasts for around two hours, because first we draw the blood, normally between 150 and 200 mL, which is no problem. And then afterwards, patient also get a vitamin infusion, and we already start giving the patient some vitamin D. Then the blood sample goes into our laboratory, and the patient has seven days off, meaning patient can either go to Munich, which has beautiful museums, a beautiful zoo by the way, or stays here in the region with a very... between Munich and the Alps. Also a very nice vacation region. Many patients always just stay for one week here to relax and calm down after all the stress. After seven days, patients come back. The dendritic cells are here already. Patients get their dendritic cells injected, and again, an infusion with vitamins and the vitamin D injection. Meaning, in total, the patient has to come three times to us as an outpatient. Uh, it's not painful despite the injections, but I think this is not a big problem. Side effects that we see are some flu-like symptoms on the day when the patients get, uh, their dendritic cells back. But what means flu-like symptoms? I always explain it that way. The feeling you have before you get the next day sick. So this not-so-well feeling. But not more, s- uh, on side effects we see. Patients can also travel, then, uh, back immediately. Some patients just come for the first two days, and then they travel back to their home countries and f- come back then after seven days. These are our fly-in-fly-out patients, which is also no problem because Munich Airport is a very big airport in Germany. It's very close t- to our clinic. So... this is the way, what the patient experience here. The most work the patients don't see because this happens in the laboratory where we produce the dendritic cells."},{"@type": "VideoObject","name": "Was passiert, wenn die DCT nicht wirkt?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_whathappenifdctfails.jpg","contentUrl": "https://vimeo.com/1047365700","transcript": "What criteria do our produced dendritic cells need to fulfill? First of all, this is, uh, given by the authorities, it must be, of course, uh, not contaminated. For this, we make regularly testings during the production process. It's... The number of the cells must be good, meaning, in our case, more than one million dendritic cells produced. What happens if we do not reach this criteria, which happens in around 1% of the production? Well, then we repeat the production without further costs, and we repeat it so long until we have produced enough dendritic cells for our patient in a very good quality."},{"@type": "VideoObject","name": "Muss ich meine Ernährung umstellen?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_doineedtochangemydiet.jpg","contentUrl": "https://vimeo.com/1047195755","transcript": "Many patients ask me, 'Do you-- I have to change my lifestyle?' Of course, you have to. Why? We're making immune therapy, and therefore, we need a very well-working immune system. Are there special hints? Let's say like this. Uh, there was a big study from the WHO several years ago, the PURE study, where they investigated influences. What shall I eat? Unsaturated fatty acid, omega-3, all the things were investigated in millions of people over many, many years. What did they fi- uh, find out? They found out it's not so important what you eat. It is important what quality you eat, meaning... ecologic-breeded chicken, for example, or organic things. Of course, they are much better than, uh, if you eat every day a frozen pizza. The other thing we also recommend to the patient, that your body has a higher need of vitamins. This you can supplement by infusions, but you also can supplement it by daily intake from vitamins, which you easily can get in your local pharmacy. On the other hand, we also must have a look that we have a higher protein need in cancer patients. For this reason, we always recommend to have a protein-rich diet for the patients. This is not only for patients undergoing dendritic cell therapy. This should be the advice for every cancer patient."},{"@type": "VideoObject","name": "Wie integriere ich DCT in meinen Chemotherapiezyklus?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_fitinchemocycle.jpg","contentUrl": "https://vimeo.com/1047359494","transcript": "What is the perfect timing for making a de- dendritic cell therapy when chemotherapy is planned or actually running? The ideal point of time, of course, is that we have, uh, the most possible time span between the last chemotherapy and taking the blood for the dendritic cells. Since chemotherapy is always in a special schedule... And we always find a place when it's far, most far away from the last chemotherapy. Giving back the dendritic cell is not such a crucial point. Of course, there should be no chemotherapy actually running, meaning by a pump or something like that. But since the dendritic cells are not dividing anymore, they are not harmed that much by chemotherapy. So, the crucial point more is when to take the blood, not so much when giving back the dendritic cells."},{"@type": "VideoObject","name": "Sollte ich DCT anstelle einer Standardtherapie verwenden?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_shoudliusedct.jpg","contentUrl": "https://vimeo.com/1047362590","transcript": "So the question is, can I use dendritic cell therapy instead of the standard therapies? For this, we must know that dendritic cell therapy is quite young. Well, people say dendritic cell therapy exist since more than 20 years. 20 years in medicine is very young. So we do not have enough data that provide evidence to say, yes, you can use dendritic cell therapy instead of the classical standard therapy. We only use, or most the time we are using the dendritic cell therapy additional to the standard therapy."},{"@type": "VideoObject","name": "Werde ich mehr als eine Dosis benötigen?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_morethanonedose.jpg","contentUrl": "https://vimeo.com/1047419593","transcript": "So, the question is, how often do we have to make a dendritic cell therapy? Let's say like this. In the adjuvant situations, our data showed evidence that one dendritic cell therapy is enough. The argument in the palliative situation for repeating dendritic cell therapy is that tumor cells also change. And of course, in the moment we make a dendritic cell therapy, we can make the pulsing against the current tumor, not, uh, pulsing against the tumor which will be in, for example, one here. This is the argument for repeating this. Since there are no very evident data so far, how often and about the scheduling, how often and in which time periods we have to make a dendritic cell therapy, this decision is always made together with the patient, discussing the pros and the contras."},{"@type": "VideoObject","name": "Was ist einzigartig an DCT mit LDG?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover-uniqueProcessNoFreezing.jpg","contentUrl": "https://vimeo.com/1047364991","transcript": "So, what, what is the specialty from us? Our big difference is that, uh, we do not freeze and thaw the cells. The production process is normally finished over s- after seven days, and mostly the, uh, laboratories freeze then the cells and give them back in portion normally every two to four weeks. Meaning we have then... the patient has to come back for four, six, or eight injections. We give all the cells back without freezing them, making all these security examinations on the day of the harvest of the cell. And this is due to the thought that, uh, a cell live, of course, longer when it does not undergo a freezing/thawing cycle, but comes out, as we always say, fresh from the laboratory directly into the patient."},{"@type": "VideoObject","name": "Was ist der Beitrag von LDG zum Bereich der DCT?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover-contributionToField.jpg","contentUrl": "https://vimeo.com/1047189540","transcript": "So what was my personal impact, or what was better said, the impact of all my group, because it's not only me, it's, uh, a lot of people working in, uh, the LDG. Our impact was more in product safety, meaning to make one product once good is easy. To make it always good is very difficult, to make the product safe. Anyhow, how we produce is eagerly observed by our authorities. So in Germany, we are controlled by our provincial authorities and the federal authorities, and as... The highest authority is European medical agencies, uh, controlling us. And our impact was, besides technical things, uh, especially that we were the first one who showed that dendritic cells have a very, very good result also in the adjuvant situation. So far most studies are made in the palliative situation. Palliative means not all tumor is taken out or away, so we try to prolong the survival of the patients or bring them into a stage that they are not palliative anymore. In the adjuvant situation, it is that we try to avoid the relapse rates, meaning the disease-free survival counts. And there we were really the first ones who did it in a large serial, showing in colorectal cancer that in the adjuvant situation, we can dramatically decrease the relapse rates in an observation period of, of more than five years."},{"@type": "VideoObject","name": "Wie aufwendig ist der Aufbau eines Labors?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover6x4_howchallengingsettinguplab.jpg","contentUrl": "https://vimeo.com/1047357377","transcript": "How long does it take to establish such a laboratory? Let's say like this. When people ask me, 'Frank, you've done so much research in your life d- during the last 30 years, even more, what was the most difficult part?' In the first decade, let's say, or the first one and a half decades, I was doing research, which is really exciting, interesting. The most hard stuff was to establish a dendritic cell laboratory which does not only produce once good dendritic cells, but which produces with an accuracy of more than 99% all the time, that it's bringing something in serial production. This was the biggest challenge in my life. This complete process took us more than 10 years to develop it. A- and I know it from also the few colleagues, I always say, not competitors, my two few colleagues here, uh, it took so long to establish everything. The reason is because if you, if you, uh, want to make a very easygoing production, you need a lot of automatization processes, and crucial steps are still bound to people's work, meaning you have a lot of very high qualified people doing the work. You cannot just write an advertiser and you can need now somebody who's, can do this. Also, these people grow with the time into their function. For this reason, to reach these very high standards which are set by the, uh, governmental authorities, but also by the European medical agencies, only a few laboratories so far established and produce in a very good quality."},{"@type": "VideoObject","name": "Wie wird DCT reguliert?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover-labRegulationCert.jpg","contentUrl": "https://vimeo.com/1047361140","transcript": "So, what are the technical terms and conditions of producing or generating dendritic cell therapies? This is very clearly regulated by the law, the European law, but also by the German law. Dendritic cells are classified as ATMPs, meaning they underlie the drug law, the Arzneimittelgesetz in German. What does it mean? It is regulated that dendritic cells must be produced like a drug is produced from a pharmaceutical company. There are very clear definitions about quality assurance, about quality control. For example, in our clean room, where we produce the dendritic cells, we work at an atmosphere of zero particles per cube meter. Meaning w-the people working inside the laboratory, inside the clean room, have spec-special protection, uh, not for themselves, but for protecting the product, which are the cells. We are regularly controlled, which is also very important. And what we always see that there are, um, some who are not producing, uh, according to these laws. But it's easy for everyone to see because the ones who have a production permission and have a GMP certificate, they all have it on their websites."},{"@type": "VideoObject","name": "Welchen Einfluss hat LDG auf das Feld der DCT?","uploadDate": "2025-09-01","description": "","thumbnailUrl": "https://labor-gansauge.de/cmsUploads/faqVideos/images/thumbs/cover-impactOnField-1.jpg","contentUrl": "https://vimeo.com/1047360149","transcript": "Well, what is, what is my impact in dendritic cell therapy? This is a... this is a good question. You must see it like this. In science nowadays, it is more in a way that worldwide, the people are doing research. Everybody brings a little brick to the wall, and in the end, we have a nice building where we can say, 'Yes, this is dendritic cell therapy.' Most of these things we did are of technical impact, how to culture, how to culture the cells, how to bring everything in a production line that you always produce with the same quality. This is very important because if you offer dendritic cell therapy, it must be always in the same very high, uh, quality. One thing. The other thing is that we, uh, made some analysis, uh, and about our patients, for example, for gastric cancer, pancreatic cancer, colorectal cancer, but also other cancers, and published this data. This is, in science, extremely important that we also delivered our bricks to the scientific community in terms of analysis of w- uh, outcome of patients treated with dendritic cells. Other groups worldwide did the same, and this altogether led to the, uh, picture we have today or the house we have today about this so-called fourth column in cancer therapy, the dendritic cell therapy. Everybody brought his impact, and we just brought our little one too."}]}]}